In Vitro Construction of Complex Stem Cell Microenvironments by Stencil-and-flip Cell Patterning (saf-cp)
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چکیده
Embryonic development is a complex dynamic process where spatial organization of molecular signals direct stem cells into the 3 germ layers. Recapitulating this process in vitro will greatly facilitate the mechanistic understanding of embryonic development. However, current models are unable to reproduce the complex developmental environment adequately. To realize the aim of building a complex developmental model, we developed the Stencil-and-Flip Cell Patterning (SAF-CP) technique to present multiple spatially organized microenvironments to a single population of stem cells.
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تاریخ انتشار 2009